Fast axonal transport in early experimental disc edema.

A model for fast axonal transport.

A model for fast axonal transport is developed in which the essential features are that organelles may interact with mechanochemical cross-bridges that in turn interact with microtubules, forming an organelle-engine-microtubule complex which is transported along the microtubules. Computer analysis of the equations derived to describe such a system show that most of the experimental observations...

Synoptic Alterations in Developing Cortical Infarction: An Experimental Investigation

Synaptic Alterations in Developing Cortical Infarction: An Experimental Investigation in Monkevs • The sequential synaptic alterations which occur during the early phase of developing cortical infarction in the squirrel monkey were studied with the electron microscope. Mild swelling of a few dendritic terminals and clumping of synaptic vesicles were the earliest detectable changes, being presen...

In vivo imaging of axonal degeneration and axonal transport in mouse models of multiple sclerosis

Pulse exposure of cultured rat neurons to aluminum-maltol affected the axonal transport system.

Although chronic aluminum neurotoxicity has been well established, the mechanism of the toxicity has not been elucidated yet. In order to simplify the study of the aluminum neurotoxicity, we employed the pulse exposure of cultured rat cortical neurons to 250 microM aluminum-maltol for 1 h at the early stage (6 h after plating), which resulted in abnormal distribution of neurofilament L (NFL) an...

Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI

Impaired axonal transport has been linked to the pathogenic processes of Alzheimer's disease (AD) in which axonal swelling and degeneration are prevalent. The development of non-invasive neuroimaging methods to quantitatively assess in vivo axonal transport deficits would be enormously valuable to visualize early, yet subtle, changes in the AD brain, to monitor the disease progression and to qu...